Paracetamol (4-Acetamidophenol) | CAS 103-90-2 | HPLC Grade ≥99.0% | Pharmaceutical Reference Standard

Elevate Your Research with Uncompromising Purity and Precision

In the meticulous world of scientific discovery, the integrity of your reagents is the bedrock of your data. Every calibration, every assay, and every experimental result hinges on the quality of the reference materials you use. We understand this fundamental principle. Our Paracetamol is not merely a chemical; it is a promise of reliability, a tool for innovation, and a testament to our commitment to the global research community. Meticulously synthesized, rigorously purified, and exhaustively analyzed, this High-Performance Liquid Chromatography (HPLC) Grade compound is engineered to meet the most exacting standards of modern laboratories. Whether you are developing the next generation of pharmaceuticals, unraveling complex metabolic pathways, or ensuring the quality of life-saving medications, our Paracetamol provides the foundational purity required for definitive, reproducible, and trustworthy results.

This product is the embodiment of a simple philosophy: exceptional science requires exceptional materials. We provide more than just a compound; we provide confidence, enabling researchers to push the boundaries of knowledge with the assurance that their starting point is flawless.

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Section 1: Detailed Product Specification & Chemical Identity

A comprehensive understanding of a reagent’s properties is the first step in any experimental design. Below, we provide an exhaustive breakdown of the chemical and physical characteristics of our Paracetamol.

• Common Name: Paracetamol

• Systematic IUPAC Name: N-(4-Hydroxyphenyl)acetamide

• Synonyms: 4-Acetamidophenol; APAP; Acetaminophen; N-Acetyl-p-aminophenol

• CAS Registry Number: 103-90-2

• Molecular Formula: C₈H₉NO₂

• Molar Mass: 151.163 g/mol

• Chemical Structure: Features a benzene ring substituted with a hydroxyl group (-OH) and an acetamido group (-NHCOCH₃) in the para position. This simple yet versatile structure is key to its physicochemical behavior and biological activity.

• Appearance: A uniform, free-flowing, fine crystalline powder. It is white to an off-white color, indicating a high degree of purity and the absence of significant oxidative or degradative contaminants.

• Melting Point: 169 – 172 °C. This sharp, defined melting range is a classic indicator of a highly pure crystalline substance. Any broadening of this range would suggest the presence of impurities.

• Solubility Profile:

  • Highly Soluble In: Ethanol, Methanol, Dimethyl Sulfoxide (DMSO), Dimethylformamide (DMF).

  • Sparingly Soluble In: Water (approximately 14 mg/mL at 25°C). Solubility in aqueous solutions can be enhanced with mild heating or the use of co-solvents.

  • Insoluble In: Non-polar solvents such as hexane, diethyl ether, and chloroform.

• Storage Recommendations: To ensure long-term stability and prevent hydrolysis or oxidative degradation, the product must be stored in its original, tightly sealed container in a cool, dry, and well-ventilated place. It is crucial to protect it from moisture, light, and excessive heat. The ideal storage temperature is at a controlled room temperature (15-25°C).

• Shelf Life: 36 months from the date of manufacture when stored under the recommended conditions.

• Packaging: Each 1000mg unit is securely packaged in a premium, multi-laminate, heat-sealed aluminum foil pouch. This packaging is specifically designed to provide an exceptional barrier against moisture, oxygen, and light, ensuring the product’s integrity from our facility to your lab bench. The pouch is further housed within a rigid outer box for superior protection during shipping and handling.

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Section 2: Unmatched Quality Assurance & Analytical Certification

We transcend the standard Certificate of Analysis (CoA). Our quality assurance process is integrated into every stage of production, providing you with an unparalleled level of traceability and confidence.

• Purity Specification: ≥ 99.0% (HPLC Grade). This is not a target; it is a guaranteed minimum.

• Analytical Methodology: The purity of every single production batch is unequivocally confirmed using validated High-Performance Liquid Chromatography (HPLC) methods with UV detection. This technique is the gold standard in the pharmaceutical industry for separating, identifying, and quantifying chemical compounds with extreme accuracy.

• Lot-Specific Traceability: Each pouch is clearly labeled with a unique Batch/Lot Number and the Date of Manufacture. This allows for complete traceability. The comprehensive Certificate of Analysis (CoA) for your specific batch is instantly available for download upon purchase and is also physically included with the shipment. The CoA provides the exact quantified purity percentage (often exceeding 99.5%), along with chromatographic data and results from other identity-confirming tests (e.g., FTIR, NMR).

• Impurity Profile: Our advanced purification processes ensure that common impurities such as 4-Aminophenol, isomeric compounds, and residual solvents are controlled to levels far below the thresholds specified in major pharmacopoeias (e.g., USP, Ph. Eur.).

This rigorous approach to quality control means you can integrate this reference standard into your workflows with absolute confidence, eliminating reagent variability as a source of error in your critical research.

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Section 3: Advanced Research Applications & Uses

🔬 CRITICAL NOTICE: This product is sold exclusively as a high-purity chemical reagent for controlled laboratory research applications. It is NOT for human or veterinary consumption, medicinal use, or home use.

Our Paracetamol is an indispensable tool for scientists across a diverse spectrum of disciplines:

1. Pharmaceutical Quality Control & Assurance (QC/QA): Serve as the Primary Chemical Reference Standard for the quantitative and qualitative analysis of drug products. It is essential for:

   • Assay and Potency Testing: Calibrating HPLC, GC, GC-MS, and TLC systems to accurately determine the concentration of Paracetamol in tablet, capsule, suspension, and powder formulations.

   • Stability and Degradation Studies: Monitoring the formation of impurities and degradation products (e.g., 4-Aminophenol) in drug substances and products under various stress conditions (heat, light, humidity) as part of ICH stability guidelines.

   • Dissolution Testing: Used as a standard in developing and validating dissolution methods to ensure drug products meet release specifications.

2. Analytical Method Development & Validation: This compound is a perfect model analyte for scientists tasked with:

   • Developing novel chromatographic separation techniques (HPLC, UPLC, CE).

   • Optimizing mobile phase compositions, column chemistries, and detection parameters.

   • Performing full method validation as per ICH Q2(R1) guidelines, including studies on specificity, linearity, accuracy, precision, and robustness.

3. Pharmacology & Mechanistic In Vitro Research: Paracetamol’s complex and still-debated mechanism of action makes it a fascinating subject for study.

   • COX Enzyme Inhibition Studies: Investigating its selective inhibition of cyclooxygenase isoenzymes (particularly the hypothesized COX-3) in cell-free systems and cellular models.

   • Endocannabinoid System Modulation: Researching its role in the biosynthesis and action of the endocannabinoid anandamide and its potential interaction with TRPV1 receptors.

   • Central Nervous System Studies: Exploring its serotonergic and other putative mechanisms of action in cultured neuronal models.

4. Toxicology & Metabolic Pathway Analysis: This is a critical application area where high-purity substrate is non-negotiable.

   • Hepatotoxicity Modeling: Serving as the substrate for studying the CYP450-mediated bioactivation pathway (primarily via CYP2E1 and CYP3A4) that produces the highly reactive and toxic metabolite N-Acetyl-p-benzoquinone imine (NAPQI).

   • Antidote Research: Used in in vitro models (e.g., hepatocyte cultures) to study the protective mechanisms and efficacy of antidotes like N-Acetylcysteine (NAC) and Methionine against drug-induced liver injury (DILI).

   • Metabolic Profiling: Identifying and quantifying phase I and phase II metabolites in microsomal and hepatocyte incubation systems.

5. Organic & Medicinal Chemistry Synthesis: Functions as a versatile chemical building block or precursor for the synthesis of more complex molecules, novel derivatives, and molecular probes for pharmacological testing.

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Section 4: Comprehensive Safety & Handling Protocol (GHS)

Safety is paramount. This substance must be handled with the utmost care by trained professionals in appropriately equipped laboratories.

• Hazard Classification (GHS):

  • H302: Harmful if swallowed.

  • H319: Causes serious eye irritation.

• Required Precautionary Measures (GHS P-Codes):

  • P264: Wash skin thoroughly after handling.

  • P270: Do not eat, drink, or smoke when using this product.

  • P280: Wear protective gloves/protective clothing/eye protection/face protection. (Nitrile gloves and chemical safety goggles are minimum requirements).

  • P301 + P312 + P330: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Do NOT induce vomiting.

  • P305 + P351 + P338 + P337 + P313: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

  • P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

• Handling Procedures:

  • Always use this material in a well-ventilated area, preferably within a certified chemical fume hood.

  • Avoid generating aerosols or dust. Use dust suppression practices.

  • • First Aid Measures:

  • Inhalation: Remove to fresh air. Seek medical attention if respiratory irritation occurs.

  • Skin Contact: Wash thoroughly with soap and plenty of water.

  • Eye Contact: Rinse immediately with copious amounts of water for at least 15 minutes, holding eyelids open. Seek immediate medical attention.

  • Ingestion: Immediately call a poison control center or doctor. Do not induce vomiting. Rinse mouth with water.

• Exposure Controls/Personal Protection:

  • Engineering Controls: Use local exhaust ventilation (fume hood). Ensure general room ventilation is adequate.

  • Personal Protective Equipment (PPE):

    • Eye/Face Protection: Tightly fitting safety goggles or a face shield.

    • Skin Protection: Wear nitrile or neoprene gloves and a clean lab coat or chemical-resistant apron.

    • Respiratory Protection: If adequate ventilation is not available, a respirator may be required.

❗ MANDATORY: This summary is not a substitute for the full Safety Data Sheet (SDS). You MUST read, understand, and have access to the complete SDS before handling this product. The SDS contains vital information on toxicological data, ecological information, and detailed disposal considerations.

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Section 5: Storage, Stability & Disposal

• Storage: Store in a cool, dry, well-ventilated place. Keep the container tightly sealed and locked up. Protect from light, moisture, and incompatible materials. The recommended storage temperature is between 15°C and 25°C.

• Stability & Shelf Life: The product is stable under the recommended storage conditions for 36 months from the date of manufacture.

• Disposal: The disposal of this chemical and its container must be conducted in full compliance with all applicable local, state, national, and international regulations. It must not be allowed to enter drains or the general environment. Consult your institution’s Environmental Health and Safety (EHS) department for specific protocols for disposing of pharmaceutical compounds. Typically, this involves collection as hazardous chemical waste for incineration by a licensed waste disposal contractor.

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Section 6: Ordering & Compliance Information

• Product Code: [Your Unique Product SKU Here]

• Unit Size: 1000mg

• Availability: In stock and ready for dispatch.

• Shipping: All packages are discreetly and securely packed. SDS is included physically in the shipment and is always available digitally.

• Intended Use Statement: By purchasing this product, you acknowledge and affirm that:

  1. You are a qualified research professional or institution.

  2. You will use this material solely for controlled laboratory research purposes.

  3. You understand it is NOT for diagnostic, therapeutic, cosmetic, household, food, or any other consumer use.

  4. You are responsible for ensuring that your purchase, possession, and use of this product comply with all applicable laws and regulations in your country/state.

Invest in the purity that drives progress. Add this essential HPLC Grade Paracetamol standard to your research arsenal today and experience the difference that definitive quality makes.