Levodopa en de bloed-hersenbarrière: een molecuul ontworpen rond een transportprobleem
PubChem gives levodopa a computed XLogP3 of -2.7 and dopamine -1.0, so the standard explanation that dopamine is simply too polar to cross cannot be right. The real answer is a transporter with a strict structural checklist.
Methyleenblauw: het eerste volledig synthetische geneesmiddel en zijn tweede leven in het laboratorium
Synthesised in 1876 as a dye for cotton, methylene blue became the first synthetic compound used as a drug and never left the laboratory. This is its phenothiazinium chemistry, its two-electron redox couple and the analytical methods still built around it.
Van piracetam naar aniracetam: wat een anisoylgroep werkelijk verandert
Swapping piracetam’s acetamide arm for a 4-methoxybenzoyl substituent changes the nitrogen count, the partition coefficient and the hydrolytic stability of the molecule. This is what that single anisoyl group does, and why plasma assays chase the metabolite instead of the parent.
Adamantaanchemie: de diamantkooi achter Bromantane
A ten-carbon hydrocarbon that melts above 540 K, sublimes instead of boiling, and switches crystal form at 208.62 K without melting. This is the cage chemistry behind memantine, adapalene, saxagliptin and bromantane.
Het racetamskelet: waarom 2-oxo-1-pyrrolidineaceetamide een chemische familie werd
A five-membered lactam and a short acetamide arm are all that define the racetam skeleton. This is what the 1969 UCB patent actually claimed, where the substituents go, and why levetiracetam proves that a shared core predicts nothing about a target.
Chlodantane: het adamantaananaloog dat bijna niemand heeft gekarakteriseerd
A PubMed search for chlodantane returns a single Russian-language record from 1999, against 34 for bromantane. This article separates what the structure and the databases actually establish from what is simply absent.
Waar onderzoeksverbindingen vandaan komen: ontdekking, synthese en structuur
Accident, phenotypic screening, target-based design and metabolite follow-up put different kinds of molecule into the literature. This hub maps the routes, and decodes the lab code, the INN stem and the CAS Registry Number that follow a compound afterwards.
De toevallige oorsprong van modafinil: hoe adrafinil leidde tot een eenvoudiger molecuul
Modafinil differs from adrafinil by a single oxygen atom, and it was never the target of a discovery programme. It was found by asking what the body did to the compound that came first.