The Racetam Skeleton: Why 2-Oxo-1-Pyrrolidine Acetamide Became a Chemical Family
A five-membered lactam and a short acetamide arm are all that define the racetam skeleton. This is what the 1969 UCB patent actually claimed, where the substituents go, and why levetiracetam proves that a shared core predicts nothing about a target.
Working With Milligram Quantities: A Practical Laboratory Guide
Weighing a few milligrams, dissolving them and storing the result looks like three trivial steps. Each one has a measurable error budget, and published stability studies show which of them actually degrades a stock solution.